报告题目：RNA enzymology in translation regulation
报告人：Kathy Liu，Assistant Professor of Biochemistry and Biophysics，The University of Pennsylvania
报告人简介：Kathy Liu, Assistant Professor of Biochemistry and Biophysics, The University of Pennsylvania, Perelman School of Medicine, Department of Biochemistry and Biophysics
2018-present, Assistant Professor of Biochemistry and Biophysics
The University of Pennsylvania Perelman School of Medicine Department of Biochemistry and Biophysics
2013 - 2017, Postdoctoral Research Fellow The University of Chicago, Chicago
2008 - 2013, Ph.D. (Biochemistry) with Honors Georgia State University, Atlanta
报告摘要：My laboratory is interested in understanding enzyme-mediated RNA processing gene regulation. It has been demonstrated recently that a diverse set of enzyme-mediated modifications are found internally within RNAs, which markedly influence the fate of RNAs in the cell. Many enzymes responsible for regulating protein and DNA modifications are targets of current therapies. RNA epitranscriptomics, the study of RNA modifications, is the new frontier in this arena. However, there are many fundamentally important questions, such as whether RNA modifications synergistically impact gene regulation, a new research area that my lab spearheaded in the RNA modification field. Furthermore, we focus on a group of essential ribosomal RNA-modifying enzymes which are frequently implicated in hematopoietic disorders but with unknown mechanisms. We aim to systematically investigate both the catalytic and non-catalytic roles of these enzymes in hematopoiesis, and blood cancers with the goal to find new therapeutic approaches.